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NAC (N-acetylcysteine)

Too little signal and cells barely respond

Xiao B, Zhang M, Viennois E, Zhang Y, Wei N, Baker MT et al (2015) Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles

Translational success will require (i) rigorous preclinical-to-clinical pipelines that include long-term toxicity and biodistribution studies, (ii) GMP- compliant manufacturing to ensure reproducibility and scalability, (iii) adaptive trial designs capable of evaluating patient-specific nanotherapies, and (iv) clearer regulatory alignment across FDA/EMA to classify and approve multifunctional nanoplatforms

Most of the time, adverse effects go away when you stop using the drug, especially if you catch them early

Vitamin B12 adds another layer